Temin, H. M. 1968.“Carcinogenesis by Avian Sarcoma Viruses. X. The Decreased Requirement for Insulin-Replaceable Activity in Serum for Cell Multiplication.”International Journal of Cancer. Nov. 15; 3(6):771–87. “I can’t really remember it.” [Êàðòèíêà: _4.jpg] “If men define situations as real,” the sociologist William Isaac Thomas observed in the 1920s, “they are real in their consequences.” Embracing a hypothesis based on incomplete evidence or ideological beliefs is risk enough. But this also makes it extremely difficult to entertain alternative possibilities, unless we can reconcile them with what we have now convinced ourselves is indisputable. *59 Individuals with a single copy of this apo E4 gene are nearly three times as likely to have both heart disease and Alzheimer’s than those with none. Apo E4 is a cousin of apo B, the protein component of LDL and VLDL, and it is also found in the lipoproteins that transport triglycerides and cholesterol. Because heart-disease researchers have focused on cholesterol as the cause of heart disease, Alzheimer’s researchers tend also to refer to apo E4 as involved in cholesterol transport as though that were all it did, thus “point[ing] to a link between cholesterol and Alzheimer’s.” But this took the overly simplistic 1960s view of heart disease and used it to misdirect the Alzheimer’s research.