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Like much of the established wisdom on diet and health, this conclusion was based on very little experimental evidence. In this case, its only supporting evidence came from Sims’s overfeeding studies. These began in the mid-1960s with four small trials that led to the observation that some people will gain weight easily and others won’t, even when consuming the same quantity of excess calories. Another half dozen trials followed, each with only a handful of subjects, intending to shed light on what Sims and his collaborators called the “obvious question” of whether a carbohydrate-rich diet, independent of the calories consumed, could raise insulin levels, cause obesity, and induce hyperinsulinemia and insulin resistance. Sims and his collaborators varied thecomposition of the diets that their volunteers would then eat to excess. Some diets were “fixed carbohydrate” regimens, in which the amount of fat was increased as much as possible but the carbohydrates were limited to what the subjects would have normally consumed in their pre-experiment lives; others were “variable carbohydrate” regimens, in which both fat and carbohydrates were added to excess. Siegel, Ronald K., and Murray E. Jarvik. 1975. Drug-induced hallucinations in animals and man. InHallucinations: Behavior, Experience, and Theory, ed. R. K. Siegel Pou and her colleagues loaded about a dozen people onto the open truck bed. They sat squeezed together along its sides on simple metal benches beneath a green metal frame. Hospital security personnel wearing blue bulletproof vests joined the effort to lift patients onto the chest-high platform. Several nurses climbed aboard to accompany the patients out of the city. One still wore her neat white tights despite the heat. Leiderman, Herbert, Jack H. Mendelson, Donald Wexler, and Philip Solomon. 1958. Sensory deprivation: Clinical aspects.Archives of Internal Medicine 101:

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